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Once thought to be an artifact of microsomal systems, atypical kinetics with cytochrome P450 (CYP) enzymes have been extensively investigated in vitro and found to be substrate and species dependent. Building upon increasing reports of heterotropic CYP activation and inhibition in clinical settings, we screened a compound library of clinically approved drugs and various probe compounds to ident...
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متن کاملJohn Hunter 1728–1793
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We study the drivers of geographic variation in U.S. health care utilization, using an empirical strategy that exploits migration of Medicare patients to separate the role of demand and supply factors. Our approach allows us to account for demand differences driven by both observable and unobservable patient characteristics. Within our sample of over-65 Medicare beneficiaries, we find that 40–5...
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This paper (a) describes a defender-attacker-defender sequential game model (DAD) to plan defenses for an infrastructure system that will enhance that system’s resilience against attacks by an intelligent adversary, (b) describes a realistic formulation of DAD for defending a transportation network, (c) develops a decomposition algorithm for solving this instance of DAD and others, and (d) demo...
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ژورنال
عنوان ژورنال: The Mississippi Valley Historical Review
سال: 1942
ISSN: 0161-391X
DOI: 10.2307/1896472